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Catalog Products » Recombinant Proteins » Cytokines » Interleukin-6 (IL-6), Human

IL-6, Human

IL-6, Human

Biological Activity
IL-6, Human (Cat. No. Z03034) stimulates cell proliferation of 7TD1 cells. The ED50 for this effect is less than 0.1ng/mL.

IL-6, Human

2 μg of IL-6, Human (Cat. No. Z03034) was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie Blue staining

Synonyms 26 kDa protein, IFN-β2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2
Description Interleukin-6 (IL-6, also known as IFN-β2) is a pleiotropic cytokine that plays important roles in acute phase reactions, inflammation, hematopoiesis, bone metabolism, and cancer progression. IL-6 is secreted by T cells and macrophages to stimulate immune response. IL-6 is responsible for stimulating acute phase protein synthesis, as well as the production of neutrophils in the bone marrow. It supports the growth of B cells and is antagonistic to regulatory T cells.
Recombinant human Interleukin-6 (rhIL-6) produced in E. coli is a single non-glycosylated polypeptide chain containing 185 amino acids. A fully biologically active molecule, rhIL-6 has a molecular mass of 20.9 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Accession No Q75MH2
Species Human
Source E. coli
Biological Activity ED50 < 1 ng/ml, measured in a cell proliferation assay using TF-1 cells, corresponding to a specific activity of > 1 x 106 units/mg.
Sequence
MPVPPGEDSK DVAAPHRQPL TSSERIDKQI RYILDGISAL
RKETCNKSNM CESSKEALAE NNLNLPKMAE KDGCFQSGFN
EETCLVKIIT GLLEFEVYLE YLQNRFESSE EQARAVQMST
KVLIQFLQKK AKNLDAITTP DPTTNASLLT KLQAQNQWLQ
DMTTHLILRS FKEFLQSSLR ALRQM

Measured Molecular Weight 20.9 kDa, observed by reducing SDS-PAGE.
Purity > 95% by SDS-PAGE analysis.
Formulation Lyophilized after extensive dialysis against 1xPBS.
Reconstitution Reconstituted in ddH2O at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant human Interleukin-6 (rhIL-6) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rhIL-6 should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Note For research use only

  • IL-6, Human
  • IL-6, Human

    Biological Activity
    IL-6, Human (Cat. No. Z03034) stimulates cell proliferation of 7TD1 cells. The ED50 for this effect is less than 0.1ng/mL.

  • IL-6, Human
  • IL-6, Human

    2 μg of IL-6, Human (Cat. No. Z03034) was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie Blue staining




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Cat. No. Z03034
Size
Price
50 ug $159.00
10 ug $65.00
1 mg $1200.00
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