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Catalog Products » Recombinant Proteins » Other Catalog Proteins » Kallikrein-11, Human

Kallikrein-11, Human

Synonyms kallikrein-related peptidase 11, TLSP, hippostasin, Kallikrein-11, hK11, Hippostasin, Trypsin-like protease, Serine protease 20, PRSS20, MGC33060, EC 3.4.21.
Description Kallikreins are a subgroup of serine proteases having diverse physiological functions. Kallikrein-11 (KLK-11) is possible multifunctional protease.KLK11 efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers.
Recombinant human Kallikrein-11(rhKLK-11) secreted in Sf9 insect cells is a single glycosylated polypeptide chain containing 232 amino acids. A fully biologically active molecule, rhKallikrein-11 has a molecular mass of 35.0 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Accession No Q9UBX7
Species Human
Source Sf9 insect cells
Biological Activity KLK-11 specific activity is > 2000 pmole/min/μg when measured by 100uM colormetric peptide substrate (D-Val-Leu-Lys-ThioBenzyl ester).
Sequence
EFAATMLLVN QSHQGFNKEH TSKMVSAIVL YVLLAAAAHS
AFAHHHHHHG SGSDDDDKET RIIKGFECKP HSQPWQAALF
EKTRLLCGAT LIAPRWLLTA AHCLKPRYIV HLGQHNLQKE
EGCEQTRTAT ESFPHPGFNN SLPNKDHRND IMLVKMASPV
SITWAVRPLT LSSRCVTAGT SCLISGWGST SSPQLRLPHT
LRCANITIIE HQKCENAYPG NITDTMVCAS VQEGGKDSCQ
GDSGGPLVCN QSLQGIISWG QDPCAITRKP GVYTKVCKYV
DWIQETMKNN

Molecular Weight 25.6
Measured Molecular Weight 35.0 kDa, observed by reducing SDS-PAGE.
Purity > 95% by SDS-PAGE and HPLC analyses.
Formulation Lyophilized after extensive dialysis against PBS, pH7.4
Reconstitution Reconstituted in ddH2O at 100μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant human Kallikrein-11(rhKLK-11) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rhKLK-11 should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Note For research use only




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Cat. No. Z03035
Size
Price
10 ug $75.00
50 ug $325.00
1 mg $3500.00