• English
  • Sign In
  • Contact Us
×
Catalog Products » Recombinant Proteins » Neurotrophins » Ciliary Neurotrophic Factor (CNTF), Human(HEK 293-expressed)

CNTF, Human(HEK 293-expressed)

Synonyms Ciliary Neurotrophic Factor
Description Ciliary neurotrophic factor (CNTF) is a polypeptide initially purified from chick embryo ocular tissue and identified as a trophic factor for embryonic chick ciliary parasympathetic neurons in culture. Subsequent studies have demonstrated that CNTF is a survival factor for additional neuronal cell types including: dorsal root ganglion sensory neurons, sympathetic ganglion neurons, embryonic motor neurons, major pelvic ganglion neurons and hippocampal neurons. CNTF has also been shown to prevent the degeneration of motor axons after axotomy. The gene for human CNTF has been localized to the proximal region of the long arm of chromosome 11. CNTF is highly conserved across species and exhibits cross-species activities. Human and rat CNTF share approximately 83% homology in their protein sequence. CNTF is structurally related to IL-6, IL-11, LIF and OSM. All of these four helix bundle cytokines share gp130 as a signal-transducing subunit in their receptor complexes.
Accession No P26441.1
Species Human
Source HEK 293
Biological Activity ED50 < 0.20 μg/ml, measured in a cell proliferation assay using TF-1 cells.
Sequence
MAFTEHSPLT PHRRDLCSRS IWLARKIRSD LTALTESYVK
HQGLNKNINL DSADGMPVAS TDQWSELTEA ERLQENLQAY
RTFHVLLARL LEDQQVHFTP TEGDFHQAIH TLLLQVAAFA
YQIEELMILL EYKIPRNEAD GMPINVGDGG LFEKKLWGLK
VLQELSQWTV RSIHDLRFIS SHQTGIPARG SHYIANNKKM

Measured Molecular Weight 22~28 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant Human Ciliary Neurotrophic Factor (CNTF) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human Ciliary Neurotrophic Factor (CNTF) should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only

  • CNTF, Human(HEK 293-expressed)
  • CNTF, Human(HEK 293-expressed)

    ED₅₀< 0.20 μg/ml, measured in a cell proliferation assay using TF-1 cells.


Cat. No.
Product Name
Price
Z03139-10
CNTF, Human - 10 ug
$59.00
Z03312-10
CNTF, Mouse - 10 ug
$60.00
Z03313-10
CNTF, Rat - 10 ug
$60.00
 



Notice there is no results found, you can visit "Citations Database" for other results.







For more documents, please visit "Technical Support".

Cat. No. Z03071
Size
Price
10 ug $49.00
50 ug $159.00