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Catalog Products » Recombinant Proteins » Cytokines » Interleukin-22 (IL-22), Human(HEK 293-expressed)

IL-22, Human(HEK 293-expressed)

Synonyms IL-TIF
Description Interleukin-22 (IL-22) is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-ß/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family.
Accession No NP_065386.1
Species Human
Source HEK 293
Biological Activity Measured by its ability to induce IL-10 secretion in COLO 205 (human colon carcinoma cells). The ED50 for this effect is less than 0.3 ng/ml.
Sequence
APISSHCRLD KSNFQQPYIT NRTFMLAKEA SLADNNTDVR
LIGEKLFHGV SMSERCYLMK QVLNFTLEEV LFPQSDRFQP
YMQEVVPFLA RLSNRLSTCH IEGDDLHIQR NVQKLKDTVK
KLGESGEIKA IGELDLLFMS LRNACI

Measured Molecular Weight 16~28 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant Human Interleukin-22 (IL-22) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human Interleukin-22 (IL-22) should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only




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Cat. No. Z03081
Size
Price
50 ug $275.00
10 ug $85.00
1 mg $2100.00