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Catalog Products » Recombinant Proteins » Growth Factors » Fas Receptor, Human

Fas R, Human

Synonyms soluble Fas receptor (sFasR), TNFRSF6, CD95, Apo I, Fas Antigen
Description Fas Receptor and Fas Ligand (FasL) belong to the TNF superfamily and are type I and type II transmembrane proteins, respectively. Binding of FasL to Fas triggers apoptosis in Fas-bearing cells. The mechanism of apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD followed by processing of the pro-enzyme to active forms. These active caspases then cleave various cellular substrates leading to the eventual cell death. sFasR is capable of inhibiting FasL-induced apoptosis by acting as a decoy receptor that serves as a sink for FasL.
Accession No NP_000034
Species Human
Source HEK 293
Biological Activity ED50 <0.4 μg/ml, measured by its ability to inhibit the cytotoxicity of Jurkat cells in the presence of 20ng/ml of human Fas Ligand.
Sequence
QVTDINSKGL ELRKTVTTVE TQNLEGLHHD GQFCHKPCPP
GERKARDCTV NGDEPDCVPC QEGKEYTDKA HFSSKCRRCR
LCDEGHGLEV EINCTRTQNT KCRCKPNFFC NSTVCEHCDP
CTKCEHGIIK ECTLTSNTKC KEEGSRS

Measured Molecular Weight 17~29 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant Human Fas Receptor remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human Fas Receptor should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only




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Cat. No. Z03082
Size
Price
10 ug $49.00
50 ug $225.00