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Catalog Products » Recombinant Proteins » Cytokines » Interleukin-5 (IL-5), Rat

IL-5, Rat

Synonyms EDF, BCDFII, TRF
Description Interleukin-5 (IL-5), produced by mast cells, T cells and eosinophils, is responsible for the activities attributed to eosinophil differentiating factor, B cell growth factor II and T cell-replacing factor (TRF). It can increase production and mobilization of eosinophils and CD34+ progenitors from the bone marrow. IL-5 plays an important role in inducing cell-mediated immunity against parasitic infections and certain tumors. IL-5 also promotes differentiation of basophils and primes them for histamine and leukotriene release.
Recombinant rat Interleukin-5 (rrIL-5) produced in E. coli is a disulfide-linked homodimer containing two non-glycosylated polypeptide chains of 113 amino acids each. A fully biologically active molecule, rrIL-5 has a molecular mass of 26.0 kDa analyzed by non-reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Accession No Q08125
Species Rat
Source E. coli
Biological Activity ED50 < 0.4 ng/mL, measured by a cell proliferation assay using TF-1 Cells, corresponding to a specific activity of > 2.5× 106 units/mg.
Sequence
MEIPMSTVVK ETLIQLSTHR ALLTSNETMR LPVPTHKNHQ
LCIGEIFQGL DILKNQTVRG GTVEILFQNL SLIKKYIDGQ
KEKCGEERRK TRHFLDYLQE FLGVMSTEWA MEV

Measured Molecular Weight 26.0 kDa, observed by non-reducing SDS-PAGE.
Purity > 95% by SDS-PAGE analysis.
Formulation Lyophilized after extensive dialysis against 20mM Tris, pH8.5.
Reconstitution Reconstituted in ddH2O at 100 μg/mL.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant rat Interleukin-5 (rrIL-5) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rrIL-5 should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Note For research use only

  • IL-5, Rat
  • IL-5, Rat

    ED₅₀< 0.4 ng/mL, measured by a cell proliferation assay using TF-1 Cells, corresponding to a specific activity of > 2.5× 10⁶ units/mg.




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Cat. No. Z03093
Size
Price
50 ug $275.00
10 ug $85.00
1 mg $2100.00
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