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Catalog Products » Recombinant Proteins » Growth Factors » Amphiregulin, Human

Amphiregulin, Human

Synonyms AR, AREG, Colorectum cell-derived growth factor (CRDGF)
Description Amphiregulin is a member of the EGF family of cytokines, which comprises at least ten proteins including EGF, TGF-α, HB-EGF, Epiregulin, Tomoregulin, Neuregulins and the various heregulins. Through the EGF/TGF-α receptor, it stimulates growth of keratinocytes, epithelial cells and some fibroblasts. Amphiregulin also inhibits the growth of certain carcinoma cell lines. Synthesized as a transmembrane protein, Amphiregulin’s extracellular domain is proteolytically processed to release the mature protein.
Accession No Q5U026
Species Human
Source HEK 293
Biological Activity ED50 < 0.2 ng/ml, measured in a cell proliferation assay using 3T3 cells.
Sequence
SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR
KKKNPCNAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER
CGEKSMKTHS MIDSSLSK

Measured Molecular Weight 15~20 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant Human Amphiregulin remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human Amphiregulin should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only




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Cat. No. Z03103
Size
Price
10 ug $39.00
50 ug $85.00