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Catalog Products » Recombinant Proteins » Growth Factors » Epidermal Growth Factor (EGF), Rat (CHO-expressed)

EGF, Rat (CHO-expressed)

Synonyms Epidermal Growth Factor, Urogastrone, URG
Description Epidermal Growth Factor, a low-molecular-weight polypeptide, is the founding member of the EGF-family of proteins. It can be found in platelets, macrophages, urine, saliva, etc. EGF acts by binding with high affinity to the Epidermal Growth Factor Receptor (EGFR) and stimulating downstream protein tyrosine kinase activity. This signal transduction cascade results in increased intracellular calcium levels and increased rates of glycolysis and protein synthesis. EGF stimulates the growth of many epidermal and epithelial tissues. Pharmaceutical drugs designed to inhibit EGFR have been used to treat certain types of cancer.
Accession No P07522
Species Rat
Source CHO
Biological Activity ED50 < 0.1 ng/ml, measured in a cell proliferation assay using 3T3 cells.
Sequence
MNSNTGCPPS YDGYCLNGGV CMYVESVDRY VCNCVIGYIG
ERCQHRDLRW WKLR

Measured Molecular Weight ~6 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE and HPLC.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant Rat Epidermal Growth Factor remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Rat Epidermal Growth Factor should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only




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Cat. No. Z03118
Size
Price
10 ug $25.00
50 ug $49.00
1 mg $425.00