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Catalog Products » Recombinant Proteins » Cytokines » Interleukin-5 Receptor alpha, Human

IL-5 Rα, Human

Synonyms IL-5RA, CD125
Description Interleukin-5 Receptor Alpha (IL-5RA), also known as CD125, belongs to the Type 5 subfamily in the type I cytokine receptor family. It is composed of a ligand-specific alpha subunit and a signal-transducing beta subunit shared by the receptors for IL-3 and GM-CSF. IL-5RA is mainly expressed on eosinophils and basophils, and plays important roles in the immunobiology of these cell types. It is reported that when stimulated by IL-5, eosinophils down-regulate surface IL-5RA expression to attenuate their IL-5 responsiveness. Elevated IL-5 production may induce immune cell infiltration which leads to allergic inflammation. IL-5RA has also been reported to promote the differentiation of basophils and B cells.
Accession No Q01344
Species Human
Source CHO
Biological Activity ED50 <0.2 ng/ml, measured in a cell proliferation assay using TF-1 cells in the presence of 1 ng/ml human IL-5.
Sequence
DLLPDEKISL LPPVNFTIKV TGLAQVLLQW KPNPDQEQRN
VNLEYQVKIN APKEDDYETR ITESKCVTIL HKGFSASVRT
ILQNDHSLLA SSWASAELHA PPGSPGTSIV NLTCTTNTTE
DNYSRLRSYQ VSLHCTWLVG TDAPEDTQYF LYYRYGSWTE
ECQEYSKDTL GRNIACWFPR TFILSKGRDW LAVLVNGSSK
HSAIRPFDQL FALHAIDQIN PPLNVTAEIE GTRLSIQWEK
PVSAFPIHCF DYEVKIHNTR NGYLQIEKLM TNAFISIIDD
LSKYDVQVRA AVSSMCREAG LWSEWSQPIY VGNDE

Measured Molecular Weight 53-56 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE and HPLC.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant Human Interleukin-5 Receptor Alpha remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human Interleukin-5 Receptor Alpha should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only




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Cat. No. Z03126
Size
Price
50 ug $385.00
10 ug $95.00
1 mg $3800.00