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IL-6, Human(CHO-expressed)

Interleukin-6 (IL-6), also known as BSF-2, CDF and IFNB2, is a pleiotropic cytokine that acts in both pro-inflammatory and anti-inflammatory responses. It is produced mainly by T cells, macrophages, monocytes, endothelial cells and muscle cells. IL-6 binds to IL-6 receptor (IL-6R) to trigger the association of IL-6R with gp130, inducing signal transduction through JAKs and STATs. The biological functions of IL-6 are diverse. It stimulates B cell differentiation and antibody production, myeloma and plasmacytoma growth, as well as nerve cell differentiation. It also acts as a myokine, produced by muscle cells in response to muscle contraction, to be released to the blood stream to help break down fats and improve insulin resistance.
$74.00
Z03134-10

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Product Introduction
Species Human
Protein Construction
IL-6 (Pro29-Met212)
Accession # Q75MH2
Purity > 95% as analyzed by SDS-PAGE
Endotoxin Level ≤ 0.2 EU/μg of protein by gel clotting method
Biological Activity ED50 < 1.0 ng/ml, measured in a cell proliferation assay using TF-1 cells.
Expression System CHO
Apparent Molecular Weight 15~25 kDa, on SDS-PAGE under reducing conditions.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml.
Storage & Stability Upon receiving, this product remains stable for 6 months at lower than -70°C. Upon reconstitution, the product should be stable for 1 week at 4°C or for 3 months at -20°C. Avoid repeated freeze-thaw cycles.
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IL-6, Human(CHO-expressed)

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IL-6, Human(CHO-expressed)

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IL-6, Human(CHO-expressed)

Biological Activity
IL-6, Human (Cat. No. Z03134) stimulates cell proliferation of 7TD1 cells.The ED50 for this effect is less than 0.06ng/mL. »

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Background
Target Background Interleukin-6 (IL-6), also known as BSF-2, CDF and IFNB2, is a pleiotropic cytokine that acts in both pro-inflammatory and anti-inflammatory responses. It is produced mainly by T cells, macrophages, monocytes, endothelial cells and muscle cells. IL-6 binds to IL-6 receptor (IL-6R) to trigger the association of IL-6R with gp130, inducing signal transduction through JAKs and STATs. The biological functions of IL-6 are diverse. It stimulates B cell differentiation and antibody production, myeloma and plasmacytoma growth, as well as nerve cell differentiation. It also acts as a myokine, produced by muscle cells in response to muscle contraction, to be released to the blood stream to help break down fats and improve insulin resistance.
Synonyms IL6; BSF-2; CDF; IFNB2; IFN-beta-2;
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For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.


Citations
Xianfang Rong, et al. Chronic Periodontitis and Alzheimer Disease: A Putative Link of Serum Proteins Identification by 2D-DIGE Proteomics. Front Aging Neurosci. (2020)