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Catalog Products » Recombinant Proteins » Cytokines » Interleukin-6 (IL-6), Human(CHO-expressed)

IL-6, Human(CHO-expressed)

Synonyms 26 kDa protein, IFN-β2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2
Description Interleukin-6 (IL-6), also known as BSF-2, CDF and IFNB2, is a pleiotropic cytokine that acts in both pro-inflammatory and anti-inflammatory responses. It is produced mainly by T cells, macrophages, monocytes, endothelial cells and muscle cells. IL-6 binds to IL-6 receptor (IL-6R) to trigger the association of IL-6R with gp130, inducing signal transduction through JAKs and STATs. The biological functions of IL-6 are diverse. It stimulates B cell differentiation and antibody production, myeloma and plasmacytoma growth, as well as nerve cell differentiation. It also acts as a myokine, produced by muscle cells in response to muscle contraction, to be released to the blood stream to help break down fats and improve insulin resistance.
Accession No Q75MH2
Species Human
Source CHO
Specific Activity ED50 < 0.06 ng/ml, measured in a cell proliferation assay using 7TD1 cells.
Sequence
PVPPGEDSKD VAAPHRQPLT SSERIDKQIR YILDGISALR
KETCNKSNMC ESSKEALAEN NLNLPKMAEK DGCFQSGFNE
ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK
VLIQFLQKKA KNLDAITTPD PTTNASLLTK LQAQNQWLQD
MTTHLILRSF KEFLQSSLRA LRQM

Measured Molecular Weight 21-23 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant Human Interleukin-6 remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, Human Interleukin-6 should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only

  • IL-6, Human(CHO-expressed)
  • IL-6, Human(CHO-expressed)

    Biological Activity
    IL-6, Human (Cat. No. Z03134) stimulates cell proliferation of 7TD1 cells.The ED50 for this effect is less than 0.06ng/mL.




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Cat. No. Z03134
Size
Price
50 ug $159.00
10 ug $65.00
1 mg $1200.00
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