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Catalog Products » Recombinant Proteins » Cytokines » IFN-gamma Receptor II (IFN-γ R II), Human

IFN-γ R II, Human

Synonyms IFNGR2, IFNGT1
Description IFN-gamma Receptor II, also known as IFNGR2 and IFNGT1, is a transmembrane protein belonging to the type II cytokine receptor family. IFNGR2 is a non-ligand-binding beta chain of the IFN-gamma receptor. It is an integral part of the IFN-gamma signaling transduction pathway and is likely to interact with GAF, JAK1 and JAK2. Defects in IFNGR2 are a cause of autosomal recessive Mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection.
Accession No P38484
Species Human
Source CHO
Biological Activity ED50 < 0.1 μg/ml, measured in a cell cytotoxicity assay using HT-29 (HTB-38) cells in the presence of 1ng/ml human IFN-gamma.
Sequence
SQLPAPQHPK IRLYNAEQVL SWEPVALSNS TRPVVYQVQF
KYTDSKWFTA DIMSIGVNCT QITATECDFT AASPSAGFPM
DFNVTLRLRA ELGALHSAWV TMPWFQHYRN VTVGPPENIE
VTPGEGSLII RFSSPFDIAD TSTAFFCYYV HYWEKGGIQQ
VKGPFRSNSI SLDNLKPSRV YCLQVQAQLL WNKSNIFRVG
HLSNISCYET MADASTELQQ

Measured Molecular Weight 38-40 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant Human IFN-gamma Receptor II remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human IFN-gamma Receptor II should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only




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Cat. No. Z03135
Size
Price
50 ug $139.00
10 ug $59.00
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