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Catalog Products » Recombinant Proteins » Cytokines » Interleukin-6 Receptor (IL-6R), Human

IL-6R, Human

Synonyms IL-6RA, IL-6R1, CD126
Description Interleukin-6 Receptor Alpha, also known as IL-6RA, IL-6R1 and CD126, belongs to the type I cytokine receptor family. It is mainly expressed on T cells, fibroblasts and macrophages. IL-6RA couples with gp130 to form the IL-6 receptor; IL-6RA binds specifically to IL-6 and depends on gp130 to transmit signals. IL-6RA dysfunction has been correlated with the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Soluble IL-6RA, which consists of only the extracellular domain of IL-6RA, acts as an agonist of IL-6 activity.
Accession No P08887
Species Human
Source CHO
Biological Activity ED50 < 0.2 μg/ml, measured in a cell proliferation assay using M1 cells in the presence of 10 ng/ml human IL-6.
Sequence
LAPRRCPAQE VARGVLTSLP GDSVTLTCPG VEPEDNATVH
WVLRKPAAGS HPSRWAGMGR RLLLRSVQLH DSGNYSCYRA
GRPAGTVHLL VDVPPEEPQL SCFRKSPLSN VVCEWGPRST
PSLTTKAVLL VRKFQNSPAE DFQEPCQYSQ ESQKFSCQLA
VPEGDSSFYI VSMCVASSVG SKFSKTQTFQ GCGILQPDPP
ANITVTAVAR NPRWLSVTWQ DPHSWNSSFY RLRFELRYRA
ERSKTFTTWM VKDLQHHCVI HDAWSGLRHV VQLRAQEEFG
QGEWSEWSPE AMGTPWTESR SPPAENEVST PMQALTTNKD
DDNILFRDSA NATSLPVQDS SSVPLP

Measured Molecular Weight 54-56 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE and HPLC.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant Human Interleukin-6 Receptor Alpha remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human Interleukin-6 Receptor Alpha should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only

  • IL-6R, Human
  • IL-6R, Human

    ED₅₀< 0.2 μg/ml, measured in a cell proliferation assay using M1 cells in the presence of human IL-6.


Cat. No.
Product Name
Price
Z03189-5
IL-6, His, Mouse - 5 ug
$65.00
Z00372-1
IL-6, Human - 1 mg
$2100.00
Z03034-10
IL-6, Human - 10 ug
$65.00
Z03134-10
IL-6, Human(CHO-expressed) - 10 ug
$65.00
Z02767-10
IL-6, Mouse - 10 ug
$159.00
Z02785-10
IL-6, Rat - 10 ug
$159.00
Z03041-5
IL-6, Rat (HEK 293-expressed) - 5 ug
$65.00
Z02759-10
IL-6, RhesusMacaque - 10 ug
$135.00
 


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Cat. No. Z03136
Size
Price
50 ug $385.00
10 ug $95.00