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Catalog Products » Recombinant Proteins » Growth Factors » Vascular Endothelial Growth Factor 121 (VEGF121), Human

VEGF121, Human

Synonyms Vascular Endothelial Growth Factor121, VPF
Description VEGF-A121 is one of five isoforms (121, 145, 165, 189, and 206) of VEGF protein, a cytokine belonging to the Platelet Differentiation Growth Factor (PDGF) family, and existing as a disulfide-linked homodimeric glycoprotein. In contrast to the longer isoforms, VEGF-A121 is more freely diffusible, and cannot bind to heparin. In vivo, VEGF is expressed predominantly in lung, heart, kidney, and adrenal glands, and the expression of VEGF is up-regulated by a number of growth factors, including PDGF, Fibroblast Growth Factor (FGF), Epidermal Growth Factor (EGF), and Tumor Necrosis Factor (TNF). VEGF signals via binding to two tyrosine kinase receptors: the Fms-like tyrosine kinase 1 (Flt-1) and the kinase domain receptor (KDR). VEGF is a specific mitogen and survival factor, contributing to abnormal angiogenesis and cancer development.
Recombinant human VEGF-A121 (rhVEGF-A121) produced in E. coli is a disulfide-linked homodimer containing two non-glycosylated polypeptide chains of 121 amino acids each. A fully biologically active molecule, rhVEGF-A121 has a molecular mass of 28.2 kDa analyzed by non-reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Species Human
Source E. coli
Biological Activity ED50 < 5 ng/mL, measured by a cell proliferation assay using HUVEC Cells, corresponding to a specific activity of > 2× 105 units/mg.
Sequence
MPMAEGGGQN HHEVVKFMDV YQRSYCHPIE TLVDIFQEYP
DEIEYIFKPS CVPLMRCGGC CNDEGLECVP TEESNITMQI
MRIKPHQGQH IGEMSFLQHN KCECRPKKDR ARQEKCDKPR
R

Measured Molecular Weight 28.2 kDa, observed by non-reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE and HPLC.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant human VEGF-A121 (rhVEGF-A121) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rhVEGF-A121 remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Note For research use only

  • VEGF121, Human
  • VEGF121, Human

    ED₅₀< 5 ng/mL, measured by a cell proliferation assay using HUVEC Cells, corresponding to a specific activity of > 2× 10⁵ units/mg.


Cat. No.
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Cat. No. Z03140
Size
Price
10 ug $85.00
50 ug $275.00