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Catalog Products » Recombinant Proteins » Growth Factors » Proheparin-binding EGF-like Growth Factor (HB-EGF), Human

HB-EGF, Human

Synonyms DTR, DTS, HEGFL
Description Proheparin-binding EGF-like growth factor (HB-EGF), also known as DTR, DTS and HEGFL, is a member of the EGF family of mitogens. It is expressed in macrophages, monocytes, endothelial cells and muscle cells. HB-EGF signals through the EGF receptor to stimulate the proliferation of smooth muscle cells, epithelial cells and keratinocytes. Compared to EGF, HB-EGF binds the EGF receptor with higher affinity and is thus more mitogenic, probably due to its ability to bind to heparin and heparin sulfate proteoglycans. HB-EGF has been reported to act as a diphtheria toxin receptor, mediating endocytosis of the bound toxin.
Accession No Q99075
Species Human
Source CHO
Biological Activity ED50 <0.5 ng/ml, measured in a cell proliferation assay using 3T3 cells.

Measured Molecular Weight 12-14 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE and HPLC.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant Human HB-EGF remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human HB-EGF should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only

  • HB-EGF, Human
  • HB-EGF, Human

    ED₅₀<0.5 ng/ml, measured in a cell proliferation assay using 3T3 cells.

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Cat. No. Z03142
5 ug $25.00
25 ug $75.00
1 mg $750.00