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Catalog Products » Recombinant Proteins » Growth Factors » Fibroblast Growth Factor-9 (FGF-9), Mouse

FGF-9, Mouse

Synonyms Growth Factor-9, GAF (Glia-activating factor), HBGF-9
Description Fibroblast Growth Factor-9 (FGF-9) is a pleiotropic cytokine and belongs to the heparin-binding FGF family. Like other members in the family, FGF-9 resembles a β-trefoil structure. FGF-9 undergoes reversible dimerization, a common characteristic shared by its subfamily members, FGF-16 and FGF-20. The mutations involved in the homodimerization also affect the affinity for heparin, binding to FGF receptors, and biological activity. In vivo, FGF-9 is expressed in limb buds, the developing skeleton, and in the intestines during late stage embryogenesis. FGF-9 is essential for the development of heart, lung, kidney, cecum, and testes; and the reduction of FGF-9 level leads to premature differentiation. FGF-9 also works along with Bone Morphogenetic Protein-7 (BMP-7) to promote the survival of nephron progenitors.
Recombinant mouse Fibroblast Growth Factor (rmFGF-9) produced in E. coli is a single non-glycosylated polypeptide chain containing 207 amino acids. A fully biologically active molecule, rmFGF-9 has a molecular mass of 23.4 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Accession No P54130
Species Mouse
Source E. coli
Biological Activity ED50 < 5 ng/mL, measured by a cell proliferation assay using 3T3 cells, corresponding to a specific activity of > 2×105 units/mg.
Sequence
MPLGEVGSYF GVQDAVPFGN VPVLPVDSPV LLNDHLGQSE
AGGLPRGPAV TDLDHLKGIL RRRQLYCRTG FHLEIFPNGT
IQGTRKDHSR FGILEFISIA VGLVSIRGVD SGLYLGMNEK
GELYGSEKLT QECVFREQFE ENWYNTYSSN LYKHVDTGRR
YYVALNKDGT PREGTRTKRH QKFTHFLPRP VDPDKVPELY
KDILSQS

Measured Molecular Weight 23.4 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE and HPLC.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O at 100 μg/mL.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant mouse Fibroblast Growth Factor (rmFGF-9) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rmFGF-9 remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Note For research use only




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Cat. No. Z03145
Size
Price
10 ug $85.00
50 ug $195.00
1 mg $1750.00