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Catalog Products » Recombinant Proteins » Cytokines » Interleukin-4 Receptor (IL-4 R), Human

IL-4 R, Human

Synonyms IL-4R, IL-4RA, CD124
Description Interleukin-4 Receptor, also known as IL-4RA and CD124, is a transmembrane glycoprotein belonging to the class I receptor family. It is highly expressed by activated T-cells. IL-4RA couples with γ chain to form the type I receptor for IL-4. The extracellular domain of IL-4RA binds to IL-4 and antagonizes its activity. IL-4RA plays an important role in Th2 cell differentiation, Ig class switching and alternative macrophage activation. It has also been implicated in allergic inflammation, tumor progression and atherogenesis.
Accession No P24394
Species Human
Source HEK 293
Specific Activity ED50 < 70 ng/ml, measured in a neutralization assay using TF-1 cells in the presence of 0.5ng/ml h-IL-4.
Sequence
GNMKVLQEPT CVSDYMSIST CEWKMNGPTN CSTELRLLYQ
LVFLLSEAHT CIPENNGGAG CVCHLLMDDV VSADNYTLDL
WAGQQLLWKG SFKPSEHVKP RAPGNLTVHT NVSDTLLLTW
SNPYPPDNYL YNHLTYAVNI WSENDPADFR IYNVTYLEPS
LRIAASTLKS GISYRARVRA WAQCYNTTWS EWSPSTKWHN
SYREPFEQH

Measured Molecular Weight 40-45 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE and HPLC.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant Human Interleukin-4 Receptor remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, Human Interleukin-4 Receptor should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only

  • IL-4 R, Human
  • IL-4 R, Human

    ED₅₀< 70 ng/ml, measured in a neutralization assay using TF-1 cells in the presence of IL-4,Human(Z02925).




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Cat. No. Z03150
Size
Price
50 ug $385.00
10 ug $95.00
1 mg $3800.00
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