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Catalog Products » Recombinant Proteins » Growth Factors » Transforming Growth Factor-alpha (TGF-α), Human

TGF-α, Human

Synonyms Transforming Growth Factor-α, Sacroma growth factor, TGF-type I, ETGF
Description Protransforming Growth Factor-alpha (TGF-alpha), also known as sarcoma growth factor, TGF-type I and ETGF, is a member of the EGF family of cytokines. It is expressed in monocytes, brain cells, keratinocytes and various tumor cells. ProTGF-alpha signals through EGFR and acts synergistically with TGF-beta to promote the proliferation of a wide range of epidermal and epithelial cells. It may function as either a membrane-bound ligand or a soluble ligand. Membrane-bound proTGF-alpha plays a role in cell-cell adhesion and juxtacrine stimulation of adjacent cells. The soluble form of the cytokine is released from the membrane-bound form by proteolytic cleavage and acts as a mitogen for cell proliferation.
Accession No P01135
Species Human
Source CHO
Biological Activity ED50 < 0.4 ng/ml, measured in a cell proliferation assay using 3T3 cells.
Sequence
VVSHFNDCPD SHTQFCFHGT CRFLVQEDKP ACVCHSGYVG
ARCEHADLLA

Measured Molecular Weight 8-10 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE and HPLC.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant Human TGF-alpha remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human TGF-alpha should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only




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Cat. No. Z03151
Size
Price
5 ug $25.00
25 ug $49.00