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Catalog Products » Recombinant Proteins » Other Catalog Proteins » Nephroblastoma Overexpressed Gene Protein (NOV), Human

NOV, Human

Synonyms Nephroblastoma Overexpressed gene, CCN3, IGFBP9, NovH
Description Nephroblastoma Overexpressed Gene Protein (NOV), also known as CCN3, IGFBP9 and NOVH, is one of the CCN family of secreted proteins. It is expressed in bone marrow, thymic cells and nephroblastoma. NOV signals through integrin receptors, NOTCH1 and fibulin 1c to regulate multiple cellular activities, such as cell adhesion, migration, proliferation and differentiation. The reported functions of NOV are diverse. It has been reported to play a role in angiogenesis and stem cell self-renewal. It has also been implicated in osteogenic differentiation, embryo development and cancer pathogenesis.
Accession No P48745
Species Human
Source CHO
Biological Activity ED50 < 5 μg/ml, measured in a cell proliferation assay using 3T3 cells.
Sequence
TQRCPPQCPG RCPATPPTCA PGVRAVLDGC SCCLVCARQR
GESCSDLEPC DESSGLYCDR SADPSNQTGI CTAVEGDNCV
FDGVIYRSGE KFQPSCKFQC TCRDGQIGCV PRCQLDVLLP
EPNCPAPRKV EVPGECCEKW ICGPDEEDSL GGLTLAAYRP
EATLGVEVSD SSVNCIEQTT EWTACSKSCG MGFSTRVTNR
NRQCEMLKQT RLCMVRPCEQ EPEQPTDKKG KKCLRTKKSL
KAIHLQFKNC TSLHTYKPRF CGVCSDGRCC TPHNTKTIQA
EFQCSPGQIV KKPVMVIGTC TCHTNCPKNN EAFLQELELK
TTRGKM

Measured Molecular Weight 20-50 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE and HPLC.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant Human NOV remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human NOV should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only




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Cat. No. Z03152
Size
Price
10 ug $59.00
50 ug $195.00
1 mg $1500.00