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Catalog Products » Recombinant Proteins » Growth Factors » Fibroblast Growth Factor-10 (FGF-10), Mouse

FGF-10, Mouse

Synonyms Fibroblast Growth Factor-10, FGFA, Keratinocyte growth factor-2
Description Fibroblast Growth Factor-10 (FGF-10) is a mitogen mainly produced by mesenchymal stem cells in lung. FGF-10 belongs to the heparin binding FGF family, and is also known as Keratinocyte Growth Factor-2 (KGF-2). It shares homology with KGF, and both KGF and FGF-10 activate the receptor FGFR2-IIIb. However, unlike KGF, which induces the proliferation and differentiation of various epithelial cells, FGF-10 is an essential factor for the budding and branching morphogenesis during multi-organ development via mesenchymal-epithelial interactions. FGF-10 is crucial for lung and limb development and is regulated by Shh during early development.
Recombinant mouse Fibroblast Growth Factor-10 (rmFGF-10) produced in E. coli is a single non-glycosylated polypeptide chain containing 148 amino acids. A fully biologically active molecule, rmFGF-10 has a molecular mass of 17.0 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Accession No O35565
Species Mouse
Source E. coli
Biological Activity ED50 < 10 ng/mL, measured by a cell proliferation assay using 4MBr-5 cells, corresponding to a specific activity of > 1.0× 105 units/mg.
Sequence
SSAGRHVRSY NHLQGDVRWR RLFSFTKYFL TIEKNGKVSG
TKNEDCPYSV LEITSVEIGV VAVKAINSNY YLAMNKKGKL
YGSKEFNNDC KLKERIEENG YNTYASFNWQ HNGRQMYVAL
NGKGAPRRGQ KTRRKNTSAH FLPMTIQT

Measured Molecular Weight 17.0 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE and HPLC.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O at 100 μg/mL.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant mouse Fibroblast Growth Factor-10 (rmFGF-10) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rmFGF-10 remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Note For research use only

  • FGF-10, Mouse
  • FGF-10, Mouse

    ED₅₀< 10 ng/mL, measured by a cell proliferation assay using 4MBr-5 cells, corresponding to a specific activity of > 1.0× 10⁵ units/mg.




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Cat. No. Z03155
Size
Price
10 ug $65.00
50 ug $159.00
1 mg $1500.00