×
Catalog Products » Recombinant Proteins » Cytokines » Interleukin-10 (IL-10), Mouse(CHO-expressed)

IL-10, Mouse(CHO-expressed)

Synonyms B-TCGF, CSIF, TGIF
Description Interleukin-10 (IL-10), initially known as Cytokine Synthesis Inhibitory Factor (CSIF), belongs to the IL-10 family and shares more than 80% sequence homology with the Epstein-Barr Virus protein BCRFI. It is produced by many immune cells, such as T-cells, macrophages, mast cells and dendritic cells. It is usually secreted as a homodimer and, upon binding to its receptor, inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF, by activated macrophages and Th2 cells. It also displays the ability to suppress Antigen-Presenting Cell (APC) function. The net effect of Interleukin-10 appears to be inhibitory; however, stimulatory effects, such as stimulation of B cell maturation and antibody production, are also reported.
Accession No P18893
Species Mouse
Source CHO
Biological Activity ED50 <0.2 ng/ml, measured in a cell proliferation assay using MC/9 cells.
Sequence
SRGQYSREDN NCTHFPVGQS HMLLELRTAF SQVKTFFQTK
DQLDNILLTD SLMQDFKGYL GCQALSEMIQ FYLVEVMPQA
EKHGPEIKEH LNSLGEKLKT LRMRLRRCHR FLPCENKSKA
VEQVKSDFNK LQDQGVYKAM NEFDIFINCI EAYMMIKMKS

Measured Molecular Weight 21-23 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE and HPLC.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant murine Interleukin-10 remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, murine Interleukin-10 should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only




Notice there is no results found, you can visit "Citations Database" for other results.







For more documents, please visit "Technical Support".

Cat. No. Z03161
Size
Price
50 ug $275.00
10 ug $85.00
1 mg $2100.00
*
*
*
*