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Catalog Products » Recombinant Proteins » Other Catalog Proteins » Betacellulin (BTC), Mouse

Betacellulin, Mouse

Synonyms BTC
Description Betacellulin, also known as BTC, belongs to the EGF family of growth factors. It is expressed in many tissues, such as kidney, pancreas and small intestine. Betacellulin is initially synthesized as a membrane-bound precursor containing multiple EGF-like domains in its extracellular region, and is released from the membrane by proteolytic cleavage. BTC is the ligand for EGFR/ErbB receptor tyrosine kinases, and plays a role in cell growth and differentiation. BTC has been reported to promote beta cell growth and differentiation in the pancreas. Pancreas-specific expression of this gene may induce islet neogenesis and remediate hyperglycemia in type I diabetes.
Accession No Q543J8
Species Mouse
Source HEK 293
Biological Activity ED50 <0.08ng/ml, measured in a cell proliferation assay using 3T3 cells.
Sequence
DGNTTRTPET NGSLCGAPGE NCTGTTPRQK VKTHFSRCPK
QYKHYCIHGR CRFVVDEQTP SCICEKGYFG ARCERVDLFY

Measured Molecular Weight 19-24 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE and HPLC.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant murine Betacellulin remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Murine Betacellulin should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only




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Cat. No. Z03162
Size
Price
10 ug $49.00
50 ug $159.00
1 mg $1100.00