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Catalog Products » Recombinant Proteins » Growth Factors » Fibroblast Growth Factor-6 (FGF-6), Human

FGF-6, Human

Synonyms Fibroblast Growth Factor-6, HBGF-6, HST-2
Description Fibroblast Growth Factor-6 (FGF-6) is a cytokine belonging to the heparin-binding FGF family, and is structurally related to other members of FGF family, particularly FGF-4. In vivo, FGF-6 exhibits an expression profile predominantly restricted tothe myogenic lineage, and it preferentially binds to two of the FGF receptors: FGFR1 and FGFR4. FGF-6 functions in muscle regeneration, myoblast proliferation and migration, and muscle differentiation in a dose-dependent manner. In vivo high concentration of recombinant FGF-6 up-regulates and down-regulates FGFR1 and FGFR4, respectively, as FGFR1 promotes the proliferation while FGFR4 promotes the differentiation in the muscle. Besides its dual function in muscle regeneration, FGF-6 may act as a regulator of bone metabolism as well.
Recombinant human Fibroblast Growth Factor-6 (rhFGF-6) produced in E. coli is a single non-glycosylated polypeptide chain containing 169 amino acids. A fully biologically active molecule, rhFGF-6 has a molecular mass of 18.8 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Accession No P10767
Species Human
Source E. coli
Biological Activity ED50 < 2.5 ng/mL, measured by a cell proliferation assay using 3T3 cells in the presence 1 µg/mL heparin, corresponding to a specific activity of > 4× 105 units/mg.
Sequence
MGTRANNTLL DSRGWGTLLS RSRAGLAGEI AGVNWESGYL
VGIKRQRRLY CNVGIGFHLQ VLPDGRISGT HEENPYSLLE
ISTVERGVVS LFGVRSALFV AMNSKGRLYA TPSFQEECKF
RETLLPNNYN AYESDLYQGT YIALSKYGRV KRGSKVSPIM
TVTHFLPRI

Measured Molecular Weight 18.8 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE and HPLC.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O at 100 μg/mL.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant human Fibroblast Growth Factor-6 (rhFGF-6) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rhFGF-6 remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Note For research use only




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Cat. No. Z03164
Size
Price
10 ug $65.00
50 ug $159.00
1 mg $1500.00