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Catalog Products » Recombinant Proteins » Cytokines » Oncostatin M (OSM), Mouse(HEK 293-expressed)

OSM, Mouse(HEK 293-expressed)

Synonyms OSM
Description Oncostatin-M, also known as OSM, is a growth regulator belonging to the interleukin-6 group of cytokines. It is expressed mainly by monocytes, activated T cells and Kaposi’s sarcoma cells. OSM signals through two types of receptors; one is composed of gp130 and LIFR, and the other is composed of gp130 and OSMR. OSM regulates IL-6, G-CSF and GM-CSF production, and thus is involved in hematopoiesis, neurogenesis and osteogenesis. OSM displays both stimulatory and inhibitory effects, so its categorization as pro-inflammatory or anti-inflammatory cytokine is still controversial.
Accession No P53347
Species Mouse
Source HEK 293
Biological Activity ED50 < 0.4 ng/ml, measured in a cell proliferation assay using NIH-3T3 cells.
Sequence
ANRGCSNSSS QLLSQLQNQA NLTGNTESLL EPYIRLQNLN
TPDLRAACTQ HSVAFPSEDT LRQLSKPHFL STVYTTLDRV
LYQLDALRQK FLKTPAFPKL DSARHNILGI RNNVFCMARL
LNHSLEIPEP TQTDSGASRS TTTPDVFNTK IGSCGFLWGY
HRFMGSVGRV FREWDDGSTR SRR

Measured Molecular Weight 10-40 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE and HPLC.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant Murine Oncostatin-M remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Murine Oncostatin-M should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only




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Cat. No. Z03167
Size
Price
50 ug $275.00
10 ug $85.00
1 mg $2100.00