×
Catalog Products » Recombinant Proteins » Cytokines » Interleukin-18 Binding Protein (IL-18 BP), Human

IL-18 BP, Human

Synonyms Tadekinig-alfa, IL18BP
Description Interleukin-18 binding protein, also known as IL-18BP and tadekinig-alfa, is a secreted glycoprotein that contains an Ig-like C2-type domain. It is expressed in heart, lung, placenta and spleen. IL-18BP functions as an inhibitor of the proinflammatory cytokine IL-18. It binds to IL-18, prevents the binding of IL-18 to its receptor, and thus blocks IL-18-induced IFN-gamma production. The complete Ig domain has been shown to mediate the binding and neutralizing properties. IFN-gamma is able to upregulate the expression of IL-18BP, indicating that IL-18 activity is regulated by a feedback mechanism through IL-18BP.
Accession No O95998
Species Human
Source CHO
Biological Activity ED50 < 30 ng /ml, measured in a bioassay using KG-1 cells in the presence of 50ng/ml Human IL-18.
Sequence
TPVSQTTTAA TASVRSTKDP CPSQPPVFPA AKQCPALEVT
WPEVEVPLNG TLSLSCVACS RFPNFSILYW LGNGSFIEHL
PGRLWEGSTS RERGSTGTQL CKALVLEQLT PALHSTNFSC
VLVDPEQVVQ RHVVLAQLWA GLRATLPPTQ EALPSSHSSP
QQQG

Measured Molecular Weight 42-44 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE and HPLC.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant Human IL-18BP remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human IL-18BP should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only




Notice there is no results found, you can visit "Citations Database" for other results.







For more documents, please visit "Technical Support".

Cat. No. Z03168
Size
Price
50 ug $85.00
10 ug $40.00
1 mg $1049.00
*
*
*
*