• English
  • Sign In
  • Contact Us
×
Catalog Products » Recombinant Proteins » Neurotrophins » Glial-Derived Neurotrophic Factor (GDNF), Mouse

GDNF, Mouse

Synonyms Glial-Derived Neurotrophic Factor, ATF-1
Description Glial-Derived Neurotrophic Factor, also known as GDNF and ATF-1, is a neurotrophic factor belonging to the TGF-beta family. It is expressed in both central nervous system (CNS) and non-CNS tissues. GDNF signals through a receptor system composed of a RET and one of the four GFR alpha receptors. It promotes the survival and differentiation of dopaminergic neurons, and increases their high-affinity dopamine uptake. In a mouse Parkinson’s Disease model, GDNF has been shown to improve bradykinesia, rigidity, and postural instability. GDNF has also been shown to regulate kidney development, spermatogenesis and affect alcohol consumption.
Accession No P48540
Species Mouse
Source CHO
Biological Activity ED50 <8μg /ml, measured in a bioassay using C6 cells.
Sequence
MSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR
GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCESAETMY
DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDNLV
YHILRKHSAK RCGCI

Measured Molecular Weight 17-22 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE and HPLC.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant murine GDNF remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Murine GDNF should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only




Notice there is no results found, you can visit "Citations Database" for other results.







For more documents, please visit "Technical Support".

Cat. No. Z03170
Size
Price
5 ug $65.00
25 ug $175.00