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Catalog Products » Recombinant Proteins » Cytokines » Thrombopoietin (TPO), Mouse

TPO, Mouse

Synonyms Thrombopoietin, Megakaryocyte colony-stimulating factor, c-MPL Ligand, MGDF
Description Thrombopoietin (TPO), also known as C-mpl ligand, MGDF and Thpo, is a glycoprotein hormone belonging to the EPO/TPO family. It is expressed mainly in the liver, kidney and skeletal muscle. TPO binds and signals through MLP/C_MPL receptor. It stimulates the proliferation and maturation of megakaryocytes from their committed progenitor cells, and it regulates the production and circulation of platelets. TPO has also been reported to promote the apoptosis of hypoxia-sensitized neurons and to inhibit neuronal differentiation.
Accession No P40226
Species Mouse
Source CHO
Biological Activity ED50 < 2 ng /ml, measured in a proliferation assay using MO7e cells.
Sequence
SPVAPACDPR LLNKLLRDSH LLHSRLSQCP DVDPLSIPVL
LPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ
LEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPLQGRTTA
HKDPNALFLS LQQLLRGKVR FLLLVEGPTL CVRRTLPTTA
VPSSTSQLLT LNKFPNRTSG LLETNFSVTA RTAGPGLLSR
LQGFRVKITP GQLNQTSRSP VQISGYLNRT HGPVNGTHGL
FAGTSLQTLE ASDISPGAFN KGSLAFNLQG GLPPSPSLAP
DGHTPFPPSP ALPTTHGSPP QLHPLFPDPS TTMPNSTAPH
PVTMYPHPRN LSQET

Measured Molecular Weight 30-80 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml..
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant murine Thrombopoietin (TPO) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, murine Thrombopoietin (TPO) should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only




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Cat. No. Z03175
Size
Price
50 ug $225.00
10 ug $85.00
1 mg $1680.00