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Catalog Products » Recombinant Proteins » Growth Factors » IGF-BP-4, His, Human

IGF-BP-4, His, Human

Synonyms Insulin-like Growth Factor-Binding Protein 4, IBP-4, HT29-IGF-BP, colon cancer cell growth inhibitor
Description Insulin-like growth factor-binding protein 4 (IGF-BP-4), also known as IBP-4, is a secreted glycoprotein belonging to the IGFBP family. IGF-BP-4 is produced by osteoblasts, epidermis, ovarian follicles and other tissues. It binds both insulin-like growth factor (IGF) I and II, and it circulates in the plasma in both glycosylated and non-glycosylated forms. IGF-BP-4 prolongs the half-life of the IGFs and has been shown to inhibit or stimulate the growth-promoting effects of the IGFs. Pregnancy Associated Plasma Protein A (PAPP-A) proteolytically cleaves IGF-BP-4 and reduces its affinity to bind IGFs, and thus serves as an important regulator of IGF-BP-4 function.
Accession No P22692
Species Human
Source HEK 293
Biological Activity ED50 < 50 ng/ml, measured in a bioassay using FDC-P1 cells in the presence of 15ng/ml human IGF-II.
Sequence
DEAIHCPPCS EEKLARCRPP VGCEELVREP GCGCCATCAL
GLGMPCGVYT PRCGSGLRCY PPRGVEKPLH TLMHGQGVCM
ELAEIEAIQE SLQPSDKDEG DHPNNSFSPC SAHDRRCLQK
HFAKIRDRST SGGKMKVNGA PREDARPVPQ GSCQSELHRA
LERLAASQSR THEDLYIIPI PNCDRNGNFH PKQCHPALDG
QRGKCWCVDR KTGVKLPGGL EPKGELDCHQ LADSFREHHH
HHH

Measured Molecular Weight 30-35 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant human IGF-BP-4 remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, human IGF-BP-4, His should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only




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Cat. No. Z03176
Size
Price
10 ug $49.00
50 ug $225.00
1 mg $1900.00