• English
  • Sign In
  • Contact Us
Catalog Products » Recombinant Proteins » Growth Factors » Insulin-like growth factor I (IGF-I), Mouse

IGF-I, Mouse

Synonyms Insulin-like Growth Factor-I, Somatamedin C, IGF-IA
Description Insulin-like Growth Factor I (IGF-I) is a single chain 7 kDa growth-promoting polypeptide originally identified as somatomedin-c. It belongs to the IGF family of peptides, which also includes IGF-II and insulin. The gene expression of IGF-I is mainly regulated by Growth Hormone, and IGF-I executes its functions via signaling through transmembrane tyrosine receptors (IGF Receptors). Most circulating IFG-I is associated with the IGF Binding Protein 3 (IGFBP-3), and the IGFBPs may inhibit the actions of IGFs by competing against the IGF Receptors. IGF-I is active in post-natal and adult animals, and is crucial for somatic growth, as IGF-I null mice show marked retardation in utero. IGF-I is involved in carcinogenesis, and related to prostate cancer as well.
Recombinant mouse Insulin-like Growth Factor I (rmIGF-I) produced in E. coli is a single non-glycosylated polypeptide chain containing 71 amino acids. A fully biologically active molecule, rmIGF-I has a molecular mass of 7.8kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Accession No P05017
Species Mouse
Source E. coli
Biological Activity ED50 <10ng/mL, measured by a cell proliferation assay using FDC-P1 cells, corresponding to a specific activity of >1×105 units/mg.

Measured Molecular Weight 7.8 kDa, observed by reducing SDS-PAGE.
Purity > 95% by SDS-PAGE analysis.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O at 100 μg/mL.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant mouse Insulin-like Growth Factor I (rmIGF-I) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rmIGF-I remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Note For research use only

Notice there is no results found, you can visit "Citations Database" for other results.

For more documents, please visit "Technical Support".

Cat. No. Z03178
10 ug $39.00
50 ug $85.00
1 mg $625.00