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Catalog Products » Recombinant Proteins » Growth Factors » Insulin-like growth factor I (IGF-I), Mouse

IGF-I, Mouse

Synonyms Insulin-like Growth Factor-I, Somatamedin C, IGF-IA
Description Insulin-like Growth Factor I (IGF-I) is a single chain 7 kDa growth-promoting polypeptide originally identified as somatomedin-c. It belongs to the IGF family of peptides, which also includes IGF-II and insulin. The gene expression of IGF-I is mainly regulated by Growth Hormone, and IGF-I executes its functions via signaling through transmembrane tyrosine receptors (IGF Receptors). Most circulating IFG-I is associated with the IGF Binding Protein 3 (IGFBP-3), and the IGFBPs may inhibit the actions of IGFs by competing against the IGF Receptors. IGF-I is active in post-natal and adult animals, and is crucial for somatic growth, as IGF-I null mice show marked retardation in utero. IGF-I is involved in carcinogenesis, and related to prostate cancer as well.
Recombinant mouse Insulin-like Growth Factor I (rmIGF-I) produced in E. coli is a single non-glycosylated polypeptide chain containing 71 amino acids. A fully biologically active molecule, rmIGF-I has a molecular mass of 7.8kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Accession No P05017
Species Mouse
Source E. coli
Biological Activity ED50 <10ng/mL, measured by a cell proliferation assay using FDC-P1 cells, corresponding to a specific activity of >1×105 units/mg.
Sequence
MGPETLCGAE LVDALQFVCG PRGFYFNKPT GYGSSIRRAP
QTGIVDECCF RSCDLRRLEM YCAPLKPTKA A

Measured Molecular Weight 7.8 kDa, observed by reducing SDS-PAGE.
Purity > 95% by SDS-PAGE analysis.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O at 100 μg/mL.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant mouse Insulin-like Growth Factor I (rmIGF-I) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rmIGF-I remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Note For research use only




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Cat. No. Z03178
Size
Price
10 ug $39.00
50 ug $85.00
1 mg $625.00