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Catalog Products » Recombinant Proteins » Other Catalog Proteins » Betacellulin (BTC), Mouse

Betacellulin, Mouse

Synonyms BTC
Description Betacellulin is a pleiotropic cytokine that belongs to the Epidermal Growth Factor (EGF) family. Like other members of the EGF family, Betacellulin possesses a conserved sequence of 35-40 amino acids which contain 3 disulfide bonds formed by 6 cysteines. Betacellulin is unique in the EGF family since it can bind and activate a broad spectrum of ErbB receptors. Functionally, Betacellulin plays a role in the development of the pancreas by activating signaling pathways beneficial for the function, survival and regeneration of pancreatic β-cells. Additionally, Betacellulin has potential angiogenic activities and is important for the growth, development and repair of certain tissues.
Recombinant mouse Betacellulin (rmBetacellulin) produced in E. coli is a single non-glycosylated polypeptide chain containing 81 amino acids. A fully biologically active molecule, rmBetacellulin has a molecular mass of 9.2 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Accession No Q05928
Species Mouse
Source E. coli
Biological Activity ED50 <0.5ng/mL, measured by a cell proliferation assay using3T3cells, corresponding to a specific activity of>2× 106 units/mg.
Sequence
MDGNTTRTPE TNGSLCGAPG ENCTGTTPRQ KVKTHFSRCP
KQYKHYCIHG RCRFVVDEQT PSCICEKGYF GARCERVDLF
Y

Measured Molecular Weight 9.2 kDa, observed by reducing SDS-PAGE.
Purity > 95% by SDS-PAGE analysis.
Formulation Lyophilized after extensive dialysis against 50mM Tris, 300mM NaCl, pH9.0.
Reconstitution Reconstituted in ddH2O at 100 μg/mL.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant mouse Betacellulin (rmBetacellulin) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rmBetacellulin remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Note For research use only




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Cat. No. Z03192
Size
Price
10 ug $49.00
50 ug $169.00
1 mg $1100.00