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Catalog Products » Recombinant Proteins » Growth Factors » Epidermal Growth Factor Receptor (EGFR), His, Human

EGFR, His, Human

Synonyms ErbB1, HER1
Description Epidermal Growth Factor Receptor (EGFR) belongs to a family of tyrosine kinase receptors including Human EGF Receptors (HER) 2, 3, and 4 which all play important roles in cell growth and differentiation. Their primary ligands are EGF, Heparin-Binding EGF and Transforming Growth Factor α. Upon ligand binding, EGFR undergoes asymmetric dimerization, composed of an “activator” and a “receiver”. EGFR and its family members are disregulated in numerous cancers. In particular, EGFR is overexpressed in many epithelial solid tumors. Evidence suggests EGFR is an excellent target for pharmacologic intervention in Non Small Cell Lung Cancer (NSCLC) due to its high level of expression and prominent role in tumor growth and metastasis.
Recombinant human Epidermal Growth Factor Receptor (rhEGFR) with C-terminal 6xHis-tag produced in Sf9 insect cells is a single glycosylated polypeptide chain containing 627 amino acids. rhEGFR has a molecular mass of 80kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Accession No P00533
Species Human
Source Sf9 insect cells
Biological Activity Bioassay data are not available.
Sequence
LEEKKVCQGT SNKLTQLGTF EDHFLSLQRM FNNCEVVLGN
LEITYVQRNY DLSFLKTIQE VAGYVLIALN TVERIPLENL
QIIRGNMYYE NSYALAVLSN YDANKTGLKE LPMRNLQEIL
HGAVRFSNNP ALCNVESIQW RDIVSSDFLS NMSMDFQNHL
GSCQKCDPSC PNGSCWGAGE ENCQKLTKII CAQQCSGRCR
GKSPSDCCHN QCAAGCTGPR ESDCLVCRKF RDEATCKDTC
PPLMLYNPTT YQMDVNPEGK YSFGATCVKK CPRNYVVTDH
GSCVRACGAD SYEMEEDGVR KCKKCEGPCR KVCNGIGIGE
FKDSLSINAT NIKHFKNCTS ISGDLHILPV AFRGDSFTHT
PPLDPQELDI LKTVKEITGF LLIQAWPENR TDLHAFENLE
IIRGRTKQHG QFSLAVVSLN ITSLGLRSLK EISDGDVIIS
GNKNLCYANT INWKKLFGTS GQKTKIISNR GENSCKATGQ
VCHALCSPEG CWGPEPRDCV SCRNVSRGRE CVDKCNLLEG
EPREFVENSE CIQCHPECLP QAMNITCTGR GPDNCIQCAH
YIDGPHCVKT CPAGVMGENN TLVWKYADAG HVCHLCHPNC
TYGCTGPGLE GCPTNGPKIP SHHHHHH

Measured Molecular Weight 80kDa, observed by reducing SDS-PAGE.
Purity > 95% by SDS-PAGE and HPLC analyses.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O at 100 μg/mL.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant human Epidermal Growth Factor Receptor (rhEGFR) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rhEGFR remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Note For research use only




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Cat. No. Z03194
Size
Price
10 ug $85.00
50 ug $195.00
1 mg $1500.00