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Catalog Products » Recombinant Proteins » Growth Factors » EGF Receptor, His, Human

EGF R, His, Human

Synonyms ERBB, ERBB1, HER1
Description EGF Receptor,also known as ERBB, ERBB1 and HER1, is a type I transmembrane protein belonging to the tyrosine protein kinase family. It binds to a subset of EGF family ligands, including EGF, TGF-alpha, amphiregulin, EPGN, BTC, EREG and HBEGF. Ligand binding triggers receptor homo- or hetero-dimerization, which induces downstream kinase activation, tyrosine phosphorylation and cell signaling. EGF receptor signaling has been shown to regulate cell proliferation, differentiation, motility and apoptosis.
Accession No P00533
Species Human
Source CHO
Biological Activity ED50< 1 μg/ml, measured in a bioassay using 3T3 cells in the presence of 25 pg/ml human EGF.
Sequence
LEEKKVCQGT SNKLTQLGTF EDHFLSLQRM FNNCEVVLGN
LEITYVQRNY DLSFLKTIQE VAGYVLIALN TVERIPLENL
QIIRGNMYYE NSYALAVLSN YDANKTGLKE LPMRNLQEIL
HGAVRFSNNP ALCNVESIQW RDIVSSDFLS NMSMDFQNHL
GSCQKCDPSC PNGSCWGAGE ENCQKLTKII CAQQCSGRCR
GKSPSDCCHN QCAAGCTGPR ESDCLVCRKF RDEATCKDTC
PPLMLYNPTT YQMDVNPEGK YSFGATCVKK CPRNYVVTDH
GSCVRACGAD SYEMEEDGVR KCKKCEGPCR KVCNGIGIGE
FKDSLSINAT NIKHFKNCTS ISGDLHILPV AFRGDSFTHT
PPLDPQELDI LKTVKEITGF LLIQAWPENR TDLHAFENLE
IIRGRTKQHG QFSLAVVSLN ITSLGLRSLK EISDGDVIIS
GNKNLCYANT INWKKLFGTS GQKTKIISNR GENSCKATGQ
VCHALCSPEG CWGPEPRDCV SCRNVSRGRE CVDKCNLLEG
EPREFVENSE CIQCHPECLP QAMNITCTGR GPDNCIQCAH
YIDGPHCVKT CPAGVMGENN TLVWKYADAG HVCHLCHPNC
TYGCTGPGLE GCPTNGPKIP SHHHHHH

Measured Molecular Weight 95-115 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant human EGF Receptor, Hisremains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, human EGF Receptor, His should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only




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Cat. No. Z03202
Size
Price
10 ug $85.00
50 ug $195.00
1 mg $1500.00