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Catalog Products » Recombinant Proteins » Other Catalog Proteins » WISP-1, Human

WISP-1, Human

Synonyms WNT1-inducible-signaling pathway protein 1, CCN4 and Wnt-1-induced secreted protein
Description WISP-1, also known as Wnt-1-inducible-signaling pathway protein 1, CCN4 and Wnt-1-induced secreted protein, is a cysteine-rich heparin-binding Glycoprotein belonging to the CCN protein family. It is expressed in many internal organs, such as the lung, kidney and spleen. WISP-1 binds to BMP-2 and enhances mesenchymal cell proliferation and osteoblastic differentiation. , WISP-1 has also been reported to attenuate p53-mediated apoptosis and inhibit TNF-induced cell death, suggesting it may play a role intumorigenesis.
Accession No O95388
Species Human
Source CHO
Biological Activity ED50<0.5 μg/ml, measured in a bioassay using ATDC5 cells in the presence of 50 ng/ml human BMP-2.
Sequence
TALSPAPTTM DFTPAPLEDT SSRPQFCKWP CECPPSPPRC
PLGVSLITDG CECCKMCAQQ LGDNCTEAAI CDPHRGLYCD
YSGDRPRYAI GVCAQVVGVG CVLDGVRYNN GQSFQPNCKY
NCTCIDGAVG CTPLCLRVRP PRLWCPHPRR VSIPGHCCEQ
WVCEDDAKRP RKTAPRDTGA FDAVGEVEAW HRNCIAYTSP
WSPCSTSCGL GVSTRISNVN AQCWPEQESR LCNLRPCDVD
IHTLIKAGKK CLAVYQPEAS MNFTLAGCIS TRSYQPKYCG
VCMDNRCCIP YKSKTIDVSF QCPDGLGFSR QVLWINACFC
NLSCRNPNDI FADLESYPDF SEIAN

Measured Molecular Weight 44-46 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant human WISP-1 remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, human WISP-1 should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only




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Cat. No. Z03204
Size
Price
5 ug $39.00
25 ug $95.00