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Catalog Products » Recombinant Proteins » Cytokines » Noggin, Mouse(CHO-expressed)

Noggin, Mouse(CHO-expressed)

Synonyms NOG
Description Noggin, also known as NOG, is a homodimeric glycoprotein that binds to and modulates the activity of TGF-beta family ligands. It is expressed in condensing cartilage and immature chondrocytes. Noggin antagonizes bone morphogenetic protein (BMP) activities by blocking epitopes on BMPs needed for binding to their receptors.Noggin has been shown to be involved in many developmental processes, such as neural tube formation and joint formation. During development, Noggin diffuses through extracellular matrices and forms morphogenic gradients that regulate cellular responses in a concentration-dependent manner.
Accession No P97466
Species Mouse
Source CHO
Biological Activity ED50< 60 ng/ml, measured in a bioassay using ATDC5 cells in the presence of 10 ng/ml human BMP-4.
Sequence
LRAAPAGGQH YLHIRPAPSD NLPLVDLIEH PDPIFDPKEK
DLNETLLRSL LGGHYDPGFM ATSPPEDRPG GGGGPAGGAE
DLAELDQLLR QRPSGAMPSE IKGLEFSEGL AQGKKQRLSK
KLRRKLQMWL WSQTFCPVLY AWNDLGSRFW PRYVKVGSCF
SKRSCSVPEG MVCKPSKSVH LTVLRWRCQR RGGQRCGWIP
IQYPIISECK CSC

Measured Molecular Weight 29-31 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant murine Nogginremains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, murine Nogginshould be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only

  • Noggin, Mouse(CHO-expressed)
  • Noggin, Mouse(CHO-expressed)

    ED₅₀< 60 ng/ml, measured in a bioassay using ATDC5 cells in the presence of 10 ng/ml human BMP-4.




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Cat. No. Z03205
Size
Price
5 ug $39.00
25 ug $95.00