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Catalog Products » Recombinant Proteins » Growth Factors » Fibroblast Growth Factor 21 (FGF-21), His, Human

FGF-21, His, Human

Synonyms fibroblast growth factor-21, FGFL
Description FGF-21, also known as fibroblast growth factor-21 and FGFL, is a secreted growth factor belonging to theheparin-binding growth factor family. It is produced by hepatocytes in response to fatty acid stimulation. FGF-21 couples with its co-factor beta-Klotho to signal through FGFR1c and FGFR4. Signal transduction results in insulin-independent uptake of glucose by adipocytes. Clinical administration of FGF-21 induces energy expenditure, fat utilization and lipid excretion.
Species Human
Source CHO
Biological Activity ED50<0.3μg/ml, measured in a bioassay using NIH-3T3 cells.
Sequence
HPIPDSSPLL QFGGQVRQRY LYTDDAQQTE AHLEIREDGT
VGGAADQSPE SLLQLKALKP GVIQILGVKT SRFLCQRPDG
ALYGSLHFDP EACSFRELLL EDGYNVYQSE AHGLPLHLPG
NKSPHRDPAP RGPARFLPLP GLPPALPEPP GILAPQPPDV
GSSDPLSMVG PSQGRSPSYA SHHHHHH

Measured Molecular Weight 23-25kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level <0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant human FGF-21 remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, human FGF-21, His should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only




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Cat. No. Z03207
Size
Price
10 ug $69.00
50 ug $195.00
1 mg $1500.00