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Catalog Products » Recombinant Proteins » Neurotrophins » Brain-derived Neurotrophic Factor (BDNF), Human

BDNF, Human

Synonyms brain-derived neurotrophic factor, abrineurin
Description BDNF, also known as brain-derived neurotrophic factor and abrineurin, is a neurotrophin belonging to the NGF-beta family. It is expressed highly in the brain, and moderately in the heart, lung, skeletal muscle and placenta. BDNF signals through its high affinity receptor gp145/trkB to exert neurotrophic properties. It has been shown to be involved in the survival and differentiation of both the central and peripheral nervous system. Specifically, BDNF regulates synaptic transmission, axonal growth and path-finding, as well as dendritic growth and morphology.
Species Human
Source CHO
Biological Activity ED50<4μg/ml, measured in a bioassay using C6 cells.
Sequence
HSDPARRGEL SVCDSISEWV TAADKKTAVD MSGGTVTVLE
KVPVSKGQLK QYFYETKCNP MGYTKEGCRG IDKRHWNSQC
RTTQSYVRAL TMDSKKRIGW RFIRIDTSCV CTLTIKRGR

Measured Molecular Weight 12-14kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level <0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant human BDNF remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, human BDNF should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only




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Cat. No. Z03208
Size
Price
5 ug $59.00
25 ug $195.00