×
Catalog Products » Recombinant Proteins » Cytokines » Noggin, Human(CHO-expressed)

Noggin, Human(CHO-expressed)

Synonyms NOG
Description Noggin, also known as NOG, is a homodimeric glycoprotein that bindsto and modulates the activity of TGF-beta family ligands. It is expressed in condensing cartilage and immature chondrocytes. Noggin antagonizes bone morphogenetic protein (BMP) activities by blocking epitopes on BMPs needed for binding to their receptors. Noggin has been shown to be involved in many developmental processes, such as neural tube formation and joint formation. During development, Noggin diffuses through extracellular matrices and forms morphogenic gradients, regulating cellular responses dependent on the local concentration of the signaling molecule.
Species Human
Source CHO
Specific Activity ED50<2.5 ng/ml, measured in a bioassay using ATDC5 cells in the presence of 10ng/ml human BMP-4.
Sequence
QHYLHIRPAP SDNLPLVDLI EHPDPIFDPK EKDLNETLLR
SLLGGHYDPG FMATSPPEDR PGGGGGAAGG AEDLAELDQL
LRQRPSGAMP SEIKGLEFSE GLAQGKKQRL SKKLRRKLQM
WLWSQTFCPV LYAWNDLGSR FWPRYVKVGS CFSKRSCSVP
EGMVCKPSKS VHLTVLRWRC QRRGGQRCGW IPIQYPIISE
CKCSC

Measured Molecular Weight 29-31kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level <0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant human Noggin remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, human Nogginshould be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only

  • Noggin, Human(CHO-expressed)
  • Noggin, Human(CHO-expressed)

    ED₅₀<2.5 ng/ml, measured in a bioassay using ATDC5 cells in the presence of 10ng/ml human BMP-4.




Notice there is no results found, you can visit "Citations Database" for other results.







For more documents, please visit "Technical Support".

Cat. No. Z03212
Size
Price
50 ug $195.00
10 ug $65.00
*
*
*
*