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Catalog Products » Recombinant Proteins » Cytokines » Otoraplin (OTOR), Human

OTOR, Human

Synonyms FDP, MIAL
Description Otoraplin (OTOR) is a cytokine first identified in 2000 and encodes a small protein of 128 amino acids with an SH3 domain. OTOR is a homologue to CD-RAP/MIA and contains a hydrophobic N-terminal region as a signal peptide, which indicates that OTOR is mainly secreted. Researchers found that high expression of OTOR is only seen in the cochlea, demonstrating its importance in hearing. Indeed, loss of the gene produces cochlear dysfunction and otosclerosis, a hearing disorder involving the bony tissue of the ear. OTOR exerts an influence on the surrounding otic capsule and functions in the extracellular matrix of the membranous portion of the cochlea.
Recombinant human Otoraplin (rhOTOR) produced in E. coli is a single non-glycosylated polypeptide chain containing 112 amino acids. rhOTOR has a molecular mass of 12.7 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Accession No Q9NRC9
Species Human
Source E. coli
Biological Activity Data not available.
Sequence
MVHGIFMDRL ASKKLCADDE CVYTISLASA QEDYNAPDCR
FINVKKGQQI YVYSKLVKEN GAGEFWAGSV YGDGQDEMGV
VGYFPRNLVK EQRVYQEATK EVPTTDIDFF CE

Measured Molecular Weight 12.7 kDa, observed by reducing SDS-PAGE.
Purity > 95% by SDS-PAGE analysis.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O at 100 μg/mL.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant human Otoraplin (rhOTOR) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rhOTOR remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Note For research use only




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Cat. No. Z03222
Size
Price
10 ug $59.00
50 ug $195.00
1 mg $1500.00