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Catalog Products » Recombinant Proteins » Growth Factors » Flt-3 Ligand (Flt-3L), His, Mouse

Flt-3L, His, Mouse

Synonyms Fms-related tyrosine kinase 3 ligand, SL cytokine
Description Flt3L, also known as Fms-related tyrosine kinase 3 ligand and SL cytokine, is a single-pass type I membrane protein. It is expressed by stromal cells and T cells. Flt3L signals through tyrosine kinase receptor Flt3/Flk2 to stimulate the proliferation of early hematopoietic progenitor cells. It synergizes with other growth factors, such as GM-CSF, IL-3 and CSF, to promote the differentiation of both myeloid and lymphoid cells. Alternative splicing and proteolytic cleavage of membrane-bound Flt3L generates a soluble extracellular domain (ECD) isoform with full biological activity.
Accession No P49772
Species Mouse
Source CHO
Biological Activity ED50 < 10 ng /ml, measured in a cell proliferation assay using AML5 cells.
Sequence
GTPDCYFSHS PISSNFKVKF RELTDHLLKD YPVTVAVNLQ
DEKHCKALWS LFLAQRWIEQ LKTVAGSKMQ TLLEDVNTEI
HFVTSCTFQP LPECLRFVQT NISHLLKDTC TQLLALKPCI
GKACQNFSRC LEVQCQPDSS TLLPPRSPIA LEATELPEPR
PRHHHHHH

Measured Molecular Weight 24-30 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant murine Flt3L, His remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, murine Flt3L, His should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only


Cat. No.
Product Name
Price
Z02926-10
Flt-3L, Human - 10 ug
$85.00
Z02762-10
Flt-3L, RhesusMacaque - 10 ug
$175.00
 


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Cat. No. Z03227
Size
Price
10 ug $95.00
50 ug $225.00