• English
  • Sign In
  • Contact Us
×
Catalog Products » Recombinant Proteins » Enzymes and Inhibitors » Maspin, Human

Maspin, Human

Synonyms Serpin B5, PI-5
Description Maspin is a non-inhibitory member of the serpin superfamily, a group of 40-60 kDa serine protease inhibitors. Maspin was discovered in 1994 and has been identified in prostate, thymus, testis, intestine, tongue, and lung. Recently Maspin received a great deal of attention due to its potential apoptotic role in cancers. Maspin expression predicts a better prognosis for several types of carcinomas including breast, prostate, colon, and oral squamus cell carcinoma. The level of Maspin is also inversely correlated to VEGF-A, an angiogenic factor. Researchers found that Maspin may play its apoptotic role as an endogenous inhibitor of histone deacetylase I (HDAC I). Therefore, Maspin is a potential personalized marker of Non-Small Cell Lung Carcinoma (NSCLC).
Recombinant human Maspin (rhMaspin) produced in E. coli is a single non-glycosylated polypeptide chain containing 375 amino acids. rhMaspin has a molecular mass of 42.1 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
Accession No P36952
Species Human
Source E. coli
Biological Activity Data not available.
Sequence
MDALQLANSA FAVDLFKQLC EKEPLGNVLF SPICLSTSLS
LAQVGAKGDT ANEIGQVLHF ENVKDIPFGF QTVTSDVNKL
SSFYSLKLIK RLYVDKSLNL STEFISSTKR PYAKELETVD
FKDKLEETKG QINNSIKDLT DGHFENILAD NSVNDQTKIL
VVNAAYFVGK WMKKFPESET KECPFRLNKT DTKPVQMMNM
EATFCMGNID SINCKIIELP FQNKHLSMFI LLPKDVEDES
TGLEKIEKQL NSESLSQWTN PSTMANAKVK LSIPKFKVEK
MIDPKACLEN LGLKHIFSED TSDFSGMSET KGVALSNVIH
KVCLEITEDG GDSIEVPGAR ILQHKDELNA DHPFIYIIRH
NKTRNIIFFG KFCSP

Measured Molecular Weight 42.1 kDa, observed by reducing SDS-PAGE.
Purity > 95% by SDS-PAGE and HPLC analysis.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O at 100 μg/mL.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant human Maspin (rhMaspin) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rhMaspin remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Note For research use only




Notice there is no results found, you can visit "Citations Database" for other results.







For more documents, please visit "Technical Support".

Cat. No. Z03231
Size
Price
10 ug $65.00
50 ug $159.00
1 mg $1200.00