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Catalog Products » Recombinant Proteins » Chemokines » Ck beta 8‑1/CCL23, Human

Ck beta 8‑1/CCL23, Human

Synonyms Ckbeta 8‑1/CCL23, Human
Description Chemokine (C-C motif) ligand 23 (CCL23) is a small cytokine belonging to the CC chemokine family that is also known as Macrophage inflammatory protein 3 (MIP-3) and Myeloid progenitor inhibitory factor 1 (MPIF-1). CCL23 is predominantly expressed in lung and liver tissue, but is also found in bone marrow and placenta.CCL23 is highly chemotactic for resting T cells and monocytes and slightly chemotactic for neutrophils. It has also been attributed to an inhibitory activity on hematopoietic progenitor cells. CCL23 is a ligand for the chemokine receptor CCR1.
Recombinant human Ck beta 8‑1/CCL23 produced in CHO cells is a single polypeptide chain containing 92 amino acids. A fully biologically active molecule, rhCk beta 8‑1/CCL23 has a molecular mass of 10.5 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
Accession No AAC63327
Species Human
Source CHO
Biological Activity The EC50 value of human Ck beta 8‑1/CCL23 on Ca2+ mobilization assay in CHO-K1/Ga15/hCCR1 cells (human Ga15 and human CCR1 stably expressed in CHO-K1 cells) is less than 0.4 μg/ml.
Sequence
MLWRRKIGPQ MTLSHAAGFH ATSADCCISY TPRSIPCSLL
ESYFETNSEC SKPGVIFLTK KGRRFCANPS DKQVQVCVRM
LKLDTRIKTR KN

Measured Molecular Weight 10.5 kDa, observed by reducing SDS-PAGE.
Purity > 98% as analyzed by SDS-PAGE.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant human Ck beta 8‑1/CCL23 remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, human Ck beta 8‑1/CCL23 should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only




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Cat. No. Z03237
Size
Price
10 ug $59.00
50 ug $159.00
1 mg $1100.00