×
Catalog Products » Recombinant Proteins » Cytokines » Interleukin-21 (IL-21), Mouse

IL-21, Mouse

Synonyms none
Description Interleukin-21 (IL-21) belongs to the Type I four helix bundle cytokines, and shares the common cytokine receptor γ chain with IL-2, IL-4, IL-7, IL-9, and IL-15. IL-21 is expressed by CD4+ T cells, natural killer (NK) T cells, and Th17 cells. The IL-21 receptor is highly expressed on CD4+ and CD8+ B cells. IL-21 plays a pivotal role in the survival and proliferation of B cells, and their differentiation to immunoglobulin (Ig) producing cells. IL-21regulates the production of IgG1 and IgE by B cells, and diminishes the severity of allergy and asthma. In some cases, IL-21 induces B cell apoptosis. Other roles of IL-21 include regulation of the innate immune system, implication in autoimmunity, and antitumor activity.
Recombinant mouse interleukin-21 (IL-21) produced in E.coli is a single non-glycosylated polypeptide chain containing 130 amino acids. A fully biologically active molecule, rhIL-21 has a molecular mass of 15.1 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
Accession No Q9ES17.1
Species Mouse
Source E. coli
Biological Activity ED50 < 1 ng/mL, measured by its ability to stimulate the proliferation of human ANBL-6 cells, corresponding to a specific activity of > 1.0× 106 units/mg.
Sequence
MHKSSPQGPD RLLIRLRHLI DIVEQLKIYE NDLDPELLSA
PQDVKGHCEH AAFACFQKAK LKPSNPGNNK TFIIDLVAQL
RRRLPARRGG KKQKHIAKCP SCDSYEKRTP KEFLERLKWL
LQKMIHQHLS

Measured Molecular Weight 15.1 kDa, observed by reducing SDS-PAGE.
Purity > 98% as analyzed by SDS-PAGE.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant mouse interleukin-21 (IL-21) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, mouse interleukin-21 (IL-21) should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only




Notice there is no results found, you can visit "Citations Database" for other results.







For more documents, please visit "Technical Support".

Cat. No. Z03242
Size
Price
50 ug $280.00
10 ug $89.00
1 mg $2350.00
*
*
*
*