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Catalog Products » Recombinant Proteins » Other Catalog Proteins » Betacellulin (BTC), Human

Betacellulin, Human

Synonyms BTC
Description Betacellulin (BTC) is a member of the EGF family of growth factors that also includes EGF, TGF-α, Amphiregulin, HB-EGF, Epiregulin, Tomoregulin, Heregulin and Neuregulins. Mature human BTC protein exhibits 80% amino acidsimilarity with mouse BTC protein. BTC is expressed in most tissues including kidney, uterus, liver and pancreas. It is also present in body fluids, including serum, milk, and colostrum. It is synthesized primarily as a transmembrane precursor, which is then processed to a mature molecule by proteolytic events. BTC signals through the EGF receptor.
Recombinant Human Betacellulin (BTC) produced in E.coli is a single non-glycosylated polypeptide chain containing 81 amino acids. A fully biologically active molecule, rhBTC has a molecular mass of 15 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
Accession No P35070
Species Human
Source E. coli
Biological Activity The ED50 was determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells is < 0.01 ng/ml, corresponding to a specific activity of >1 x 108 units/mg.
Sequence
MDGNSTRSPE TNGLLCGDPE ENCAATTTQS KRKGHFSRCP
KQYKHYCIKG RCRFVVAEQT PSCVCDEGYI GARCERVDLF
Y

Measured Molecular Weight 15 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant human Betacellulin (BTC) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, human Betacellulin (BTC) should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only




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Cat. No. Z03244
Size
Price
10 ug $59.00
50 ug $159.00
1 mg $1350.00