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Catalog Products » Recombinant Proteins » Chemokines » ENA-78/CXCL5 (5-78aa), Human

ENA-78/CXCL5 (5-78aa), Human

Synonyms Epithelial Neutrophil Activating Peptide-78, CXCL5
Description Epithelial cell­derived neutrophil­activating peptide (ENA­78) also known as C-X-C motif chemokine 5(CXCL5), is a small cytokine belonging to the CXC chemokine family. It is produced following stimulation of cells with the inflammatory cytokines interleukin-1 or tumor necrosis factor-alpha. Expression of CXCL5 has also been observed in eosinophils, and can be inhibited with the type II interferon, IFN-γ. This chemokine stimulates the chemotaxis of neutrophils possessing angiogenic properties. Full length CXCL5 (78 aa) is trimmed at the N­terminal end by cathepsin G and chymotrypsin to ENA-74 (74 aa) and ENA-70 (70aa), with the shortened forms showing increased potency relative to full length CXCL5. CXCL5can signal through the CXCR2 receptor.
Recombinant human ENA-78/CXCL5 (5-78a.a.) produced in E.coli is a single non-glycosylated polypeptide chain containing 74 amino acids. A fully biologically active molecule, rh ENA-78/CXCL5 (5-78a.a.) has a molecular mass of 8 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
Accession No P42830
Species Human
Source E. coli
Biological Activity The EC50 value of human ENA-78/CXCL5 (5-78a.a.) on Ca2+ mobilization assay in CHO-K1/ Gα15/hCXCR2 cells (human Gα15 and human CXCR2 stably expressed in CHO-K1 cells) is less than 50 ng/ml.
Sequence
AAVLRELRCV CLQTTQGVHP KMISNLQVFA IGPQCSKVEV
VASLKNGKEI CLDPEAPFLK KVIQKILDGG NKEN

Measured Molecular Weight 8 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant human ENA-78/CXCL5 (5-78a.a.) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, human ENA-78/CXCL5 (5-78a.a.) should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only


Cat. No.
Product Name
Price
Z02820-20
ENA-78/CXCL5 (5-78aa), Human - 20 ug
$159.00
Z03271-5
ENA78/CXCL5(9-78 a.a.), Human - 5 ug
$40.00
Z03255-5
ENA-78/CXCL5, Human(HEK 293-expressed) - 5 ug
$39.00
 



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Cat. No. Z03261
Size
Price
5 ug $39.00
25 ug $95.00
1 mg $1300.00