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Catalog Products » Recombinant Proteins » Cytokines » Interferon gamma (IFN-γ), Rat

IFN-γ, Rat

Synonyms Type II interferon, T cell interferon, MAF
Description Interferon gamma (IFN-γ), also known as Type II interferon,is a cytokine produced primarily by T-lymphocytes and natural killer cells. The active form of IFN-γ is an antiparallel dimer that interacts with the receptor IFN-γR1 and activates the IFN-γ/JAK/STAT pathway. IFN-γ signaling promotesbiological functions primarily related to antiviral and antibacterial defense, apoptosis, inflammation, and regulation of innate and acquired immune responses. While IFN-γ–induced inflammatory cascades summon a variety of immune-related cell types, such as macrophages, natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), IFN-γ is also implicated in resistance to NK cell and CTL responses and in immune escape in a variety of cancers.
Recombinant Rat Interferon gamma (IFN-γ) produced in E.coli is a single non-glycosylated polypeptide chain containing 134 amino acids. A fully biologically active molecule, rrIFN-γ has a molecular mass of 15.5 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
Accession No P01581
Species Rat
Source E. coli
Biological Activity ED50 <0.5 ng/ml, measured by cytotoxicity assay using WEHI-279 cells, corresponding to a specific activity of >2×106 units/mg.
Sequence
GTLIESLESL KNYFNSSSMD AMEGKSLLLD IWRNWQKDGN
TKILESQIIS FYLRLFEVLK DNQAISNNIS VIESHLITNF
FSNSKAKKDA FMSIAKFEVN NPQIQHKAVN ELIRVIHQLS
PESSLRKRKR SRC

Measured Molecular Weight 15.5 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE and HPLC.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant Rat IFN-γ remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, recombinant Rat IFN-γ should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only




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Cat. No. Z03274
Size
Price
50 ug $55.00
10 ug $39.00
1 mg $499.00
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