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Catalog Products » Recombinant Proteins » Growth Factors » Platelet-Derived Growth Factor-AA (PDGF-AA), Mouse

PDGF-AA, Mouse

Synonyms Platelet-Derived Growth Factor-AA, Glioma-derived growth factor (GDGF), Osteosarcoma-derived Growth Factor (ODGF)
Description Platelet-Derived Growth Factor-AA (PDGF-AA) is one of five dimers (PDGF-AA, AB, BB, CC, and DD) formed by 4 different PDGF subunits. In chemical terms, platelet-derived growth factor is a dimeric glycoprotein composed of two A (-AA) or two B (-BB) chains or a combination of the two (-AB). The dimeric isoforms PDGF­AA, AB and BB are differentially expressed in various cell types, and their effects are mediated through two distinct receptors termed α and β. Differences exist in isoform binding to each receptor. Ingeneral, PDGF isoforms are potent mitogens for connective tissue cells including dermal fibroblasts, glial cells, arterial smooth muscle cells and some epithelial andendothelial cells. In addition to its activity as a mitogen, PDGF is chemotactic for fibroblasts, smooth muscle cells, neutrophils and mononuclear cells. PDGF-AA plays a significant role in blood vessel formation (angiogenesis).
Recombinant Mouse Platelet-Derived Growth Factor-AA(PDGF-AA) produced in E.coli is a disulfide-linked homodimer containing two non-glycosylated polypeptide chains of 125 amino acids each. A fully biologically active molecule, rmPDGF-AA has a molecular mass of 28.7 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
Accession No P20033
Species Mouse
Source E. coli
Biological Activity ED50 <50 ng/ml, measured in a cell proliferation assay using 3T3 cells.
Sequence
MSIEEAVPAV CKTRTVIYEI PRSQVDPTSA NFLIWPPCVE
VKRCTGCCNT SSVKCQPSRV HHRSVKVAKV EYVRKKPKLK
EVQVRLEEHL ECACATSNLN PDHREEETGR RRESGKNRKR
KRLKPT

Measured Molecular Weight 28.7 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE.
Formulation Lyophilized after extensive dialysis against 1xPBS.
Reconstitution Reconstituted in ddH2O at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant Mouse Platelet-Derived Growth Factor-AA(PDGF-AA)remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, recombinant Mouse PDGF-AA should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only


Cat. No.
Product Name
Price
Z03080-10
PDGF-CC, Human - 10 ug
$65.00
Z03195-10
PDGF-DD, Human - 10 ug
$85.00
Z02892-10
PDGF-BB, Human - 10 ug
$159.00
Z03096-10
PDGF-BB, Mouse - 10 ug
$85.00
Z03179-10
PDGF-BB, Rat - 10 ug
$85.00
 


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Cat. No. Z03276
Size
Price
10 ug $89.00
50 ug $210.00
1 mg $1750.00