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Catalog Products » Recombinant Proteins » Cytokines » Interleukin-2 Receptor α(IL-2 R α), His, Human 

IL-2 R α, His, Human 

Synonyms soluble IL-2 receptor, TAC-antigen, CD25 antigen
Description Interleukin-2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to the cytokine IL-2. The IL-2R is made up of 3 subunits - alpha (α), beta (β) and gamma (γ). The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ-chain, along with the β subunit. The β and γ chains of the IL-2R are members of the type I cytokine receptor family. IL-2R has a high binding affinity to IL-2 and is expressed by antigen-activated T lymphocytes (T cells). IL-2 Rα is also known as CD25, p55, and Tac (activated T cell) antigen.
Recombinant Human Interleukin-2 Receptor α (IL-2 R α), His produced in HEK 293 cells is a polypeptide chain containing 205 amino acids. A fully biologically active molecule, rhIL-2 R α has a molecular mass of 42 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
Accession No P01589
Species Human
Source HEK 293
Biological Activity Determined by its ability to increase the proliferation effect of IL-2 in murine CTLL-2 cells. In the presence of 1 ng/ml of recombinant IL-2, ED50 for this effect is < 1.5 µg/ml.
Sequence
HHHHHHHHEL CDDDPPEIPH ATFKAMAYKE GTMLNCECKR
GFRRIKSGSL YMLCTGNSSH SSWDNQCQCT SSATRNTTKQ
VTPQPEEQKE RKTTEMQSPM QPVDQASLPG HCREPPPWEN
EATERIYHFV VGQMVYYQCV QGYRALHRGP AESVCKMTHG
KTRWTQPQLI CTGEMETSQF PGEEKPQASP EGRPESETSC

Measured Molecular Weight 42 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE and HPLC.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant Human Interleukin-2 Receptor α remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human Interleukin-2 Receptor α should be stable up to 1 week at 4°C or up to 3 months at -20°C.
Note For research use only




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Cat. No. Z03297
Size
Price
50 ug $150.00
10 ug $59.00
1 mg $1250.00
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