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Catalog Products » Recombinant Proteins » Growth Factors » Fibroblast Growth Factor-basic (145aa), Human

FGF-basic (145aa), Human

Synonyms Fibroblast Growth Factor-basic, FGF-2, HBGF-2, Prostatropin
Description Fibroblast Growth Factor-basic (FGF-basic), also known as FGF-2, is a pleiotropic cytokine and one of the prototypic members of the heparin-binding FGF family. Like other FGF family members, FGF-basic has the β trefoil structure. In vivo, FGF-basic is produced by a variety of cells, including cardiomycotes, fibroblasts, and vascular cells. FGF-basic regulates a variety of processes including cell proliferation, differentiation, survival, adhesion, motility, apoptosis, limb formation and wound healing. FGF-basic can be tumorigenic due to its role in angiogenesis and blood vessel remodeling. The angiogenic effects of FGF-basic can produce beneficial cardioprotection during acute heart injury.
Recombinant Human FGF-basic (145a.a.)produced in E.coli is a single non-glycosylated polypeptide chain containing 145 amino acids. A fully biologically active molecule, rhFGF-basic has a molecular mass of 16.4 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
Source E. coli
Biological Activity ED50 < 0.25 ng/mL, measured by the cell proliferation assay using 3T3 cells, corresponding to a specific activity of > 4 × 106 units/mg
Ala144-Ser288 (Accession #: P09038).

Measured Molecular Weight 16.4 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant Human FGF-basic (145a.a.) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human FGF-basic (145a.a.) should be stable up to 1 week at 4°C or up to 3 months at -20°C.
Note For research use only

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Cat. No. Z03310
10 ug $40.00
50 ug $89.00
1 mg $550.00