Cathepsin L, Human

*This product has been discontinued!*

Alternative product(s) for purchase:Z03591

Cathepsin L, also known as Aldrichina grahami cysteine proteinase, is an important lysosomal endopeptidase enzyme which is involved in the initiation of protein degradation. It is a member of the Peptidase C1 family, which play an important role in diverse processes including normal lysosome mediated protein turnover, antigen and proprotein processing, and apoptosis. Cathepsin L has also been shown to proteolytically inactivate α-1-antitrypsin and secretory leucoprotease inhibitor, two major protease inhibitors of the respiratory tract. Cathepsin L expression has been reported in many organisms including fish, birds and mammals.Recombinant Human Cathepsin L produced in CHO cells is a polypeptide chain containing 227 amino acids. A fully biologically active molecule, rhCathepsin L has a molecular mass of 40 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.

Cat. No.	Z03323
Size	Buy in bulk

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Product Introduction Background

Product Introduction

Purity	> 95% as analyzed by SDS-PAGE & HPLC.
Endotoxin Level	< 0.2 EU/μg, determined by LAL method.
Formulation	Liquid after a 0.2 μm filtered solution in 50 mM NaOAc, 50 mM NaCl, 20% Glycerol, pH 6.0.

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Background

Target Background

Cathepsin L, also known as Aldrichina grahami cysteine proteinase, is an important lysosomal endopeptidase enzyme which is involved in the initiation of protein degradation. It is a member of the Peptidase C1 family, which play an important role in diverse processes including normal lysosome mediated protein turnover, antigen and proprotein processing, and apoptosis. Cathepsin L has also been shown to proteolytically inactivate α-1-antitrypsin and secretory leucoprotease inhibitor, two major protease inhibitors of the respiratory tract. Cathepsin L expression has been reported in many organisms including fish, birds and mammals.
Recombinant Human Cathepsin L produced in CHO cells is a polypeptide chain containing 227 amino acids. A fully biologically active molecule, rhCathepsin L has a molecular mass of 40 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.

Synonyms

Cathepsin L; CTSL; CTSL1

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